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2020. doi: 10.1001/jamaneurol.2020.2273.

37. G. Naeije, I. Bachir, N. Gaspard, B. Legros, and T. Pepersack. “Epileptic Activities and Older People Delirium.” Geriatr Gerontol Int 14(2) (2014): 447–451. doi: 10.1111/ggi.12128.

38. Jorge I. F. Salluh, Han Wang, Eric B. Schneider, Neeraja Nagaraja, Gayane Yenokyan, Abdulla Damluji, Rodrigo B. Serafim, and Robert D. Stevens. “Outcome of Delirium in Critically Ill Patients: Systematic Review and Meta-Analysis.” BMJ 350 (2015). doi: 10.1136/bmj.h2538.

39. Sharon K. Inouye. “Delirium in Older Persons.” N Engl J Med 354(11) (2006): 1157–65. doi: 10.1056/ NEJMra052321.

40. Robert Hatch, Duncan Young, Vicki Barber, John Griffiths, David A. Harrison, and Peter Watkinson. “Anxiety, Depression and Post Traumatic Stress Disorder after Critical Illness: A UK-Wide Prospective Cohort Study.” Crit Care 22(1) (2018): 310. doi: 10.1186/s13054-018-2223-6.

41. O. Plana-Ripoll, C. B. Pedersen, Y. Holtz, et al. “Exploring Comorbidity Within Mental Disorders Among a Danish National Population.” JAMA Psychiatry (published online January 16, 2019). doi: 10.1001/jamapsychiatry.2018.3658ArticleGoogle Scholar.

Глава 10

1. S. Umesh and S. H. Nizamie. “Genetics in Psychiatry.” Indian J Hum Genet 20(2) (2014): 120–128. doi: 10.4103/0971-6866.142845.

2. Richard Border, Emma C. Johnson, Luke M. Evans, Andrew Smolen, Noah Berley, Patrick F. Sullivan, and Matthew C. Keller. “No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.” Am J Psychiatry 176(5) (2019): 376–387. doi: 10.1176/appi.ajp.2018.18070881.

3. G. Scaini, G. T. Rezin, A. F. Carvalho, E. L. Streck, M. Berk, and J. Quevedo. “Mitochondrial Dysfunction in Bipolar Disorder: Evidence, Pathophysiology and Translational Implications.” Neurosci Biobehav 68 (Rev. September 2016): 694–713. doi: 10.1016/j.neubiorev.2016.06.040.

4. S. Michels, G. K. Ganjam, H. Martins, et al. “Downregulation of the Psychiatric Susceptibility Gene Cacna1c Promotes Mitochondrial Resilience to Oxidative Stress in Neuronal Cells.” Cell Death Dis 4(54) (2018): 54. doi: 10.1038/s41420-018-0061-6.

5. Lixia Qin, Zhu Xiongwei, and Robert P. Friedland. “ApoE and Mitochondrial Dysfunction.” Neurology 94(23) (2020): 1009. doi: 10.1212/WNL.0000000000009569.

6. Y. Yamazaki, N. Zhao, T. R. Caulfield, C. C. Liu, and G. Bu. “Apolipoprotein E and Alzheimer Disease: Pathobiology and Targeting Strategies.” Nat Rev Neurol 15(9) (2019): 501–518. doi: 10.1038/ s41582-019-0228-7.

7. J. Yin, E. M. Reiman, T. G. Beach, et al. “Effect of ApoE Isoforms on Mitochondria in Alzheimer Disease.” Neurology 94(23) (2020): e2404–e2411. doi: 10.1212/WNL.0000000000009582.

8. E. Schmukler, S. Solomon, S. Simonovitch, et al. “Altered Mitochondrial Dynamics and Function in APOE4-Expressing Astrocytes.” Cell Death Dis 11(7) (2020): 578. doi: 10.1038/s41419-020-02776-4.

9. A. L. Lumsden, A. Mulugeta, A. Zhou, and E. Hyppönen. “Apolipoprotein E (APOE) Genotype-Associated Disease Risks: A Phenome-Wide, Registry-Based, Case-Control Study Utilising the UK Biobank.” EBioMedicine 59 (2020):102954. doi: 10.1016/j.ebiom.2020.102954.

10. M. S. Sharpley, C. Marciniak, K. Eckel-Mahan, M. McManus, M. Crimi, K. Waymire, C. S. Lin, S. Masubuchi, N. Friend, M. Koike, D. Chalkia, G. MacGregor, P. Sassone-Corsi, and D. C. Wallace. “Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition.” Cell 151(2) (2012): 333–343. doi: 10.1016/j.cell.2012.09.004. PMID: 23063123; PMCID: PMC4175720.

11. Centers for Disease Control and Prevention. “What Is Epigenetics?” CDC, US Department of Health and Human Services. https://www.cdc.gov/genomics/disease/epigenetics.htm. Retrieved 10/30/21.

12. T. J. Roseboom. “Epidemiological Evidence for the Developmental Origins of Health and Disease: Effects of Prenatal Undernutrition in Humans.” J Endocrinol 242(1) (July 1, 2019): T135–T144. doi: 10.1530/ JOE-18-0683.

13. J. P. Etchegaray and R. Mostoslavsky. “Interplay Between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.” Mol Cell 62(5) (2016): 695–711. doi: 10.1016/j.molcel.2016.05.029.

14. P. H. Ear, A. Chadda, S. B. Gumusoglu, M. S. Schmidt, S. Vogeler, J. Malicoat, J. Kadel, M. M. Moore, M. E. Migaud, H. E. Stevens, and C. Brenner. “Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring.” Cell Rep 26(4) (2019): 969–983.e4. doi: 10.1016/j.celrep.2019.01.007.

15. R. Yehuda and A. Lehrner. “Intergenerational Transmission of Trauma Effects: Putative Role of Epigenetic Mechanisms.” World Psychiatry 17(3) (2018): 243–257. doi: 10.1002/wps.20568.

16. D. A. Dickson, J. K. Paulus, V. Mensah, et al. “Reduced Levels of miRNAs 449 and 34 in Sperm of Mice and Men Exposed to Early Life Stress.” Transl Psychiatry 8 (2018): 101. doi: 10.1038/s41398-018-0146-2.

17. S. Lupien, B. McEwen, M. Gunnar, et al. “Effects of Stress Throughout the Lifespan on the Brain, Behaviour, and Cognition.” Nat Rev Neurosci 10 (2009): 434–445. doi: 10.1038/nrn2639.

Глава 11

1. Julian M. Yabut, Justin D. Crane, Alexander E. Green, Damien J. Keating, Waliul I. Khan, and Gregory R. Steinberg. “Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.” Endocr Rev 40(4) (2019): 1092–1107. doi: 10.1210/er.2018-00283.

2. Sashaina E. Fanibunda, Deb Sukrita, Babukrishna Maniyadath, Praachi Tiwari, Utkarsha Ghai, Samir Gupta, Dwight Figueiredo, et al. “Serotonin Regulates Mitochondrial Biogenesis and Function in Rodent Cortical Neurons via the 5-HT2A Receptor and SIRT1–PGC-1α Axis.” Proc Natl Acad Sci USA 116(22) (2019): 11028. doi: 10.1073/pnas.1821332116.

3. M. Accardi, B. Daniels, P. Brown, et al. “Mitochondrial Reactive Oxygen Species Regulate the Strength of Inhibitory GABA-Mediated Synaptic Transmission.” Nat Commun 5 (2014): 3168. doi: 10.1038/ ncomms4168.

4. A. K. Kanellopoulos, V. Mariano, M. Spinazzi, Y. J. Woo, C. McLean, U. Pech, K. W. Li, J. D. Armstrong, A. Giangrande, P. Callaerts, A. B. Smit, B. S. Abrahams, A. Fiala, T. Achsel, and C. Bagni. “Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits.” Cell 180(6) (March 19, 2020): 1178–1197.e20. doi: 10.1016/j.cell.2020.02.044.

5. Ryutaro Ikegami, Ippei Shimizu, Takeshi Sato, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, et al. “Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity.” Cell Rep 24(11) (2018): 2827–2837.e5. doi: 10.1016/j.celrep.2018.08.024.

6. S. M. Graves, Z. Xie, K. A. Stout, et al. “Dopamine Metabolism by a Monoamine Oxidase Mitochondrial Shuttle Activates the Electron Transport Chain.” Nat Neurosci 23 (2020): 15–20.

7. D. Aslanoglou, S. Bertera, M. Sánchez-Soto, et al. “Dopamine Regulates Pancreatic Glucagon and Insulin Secretion via Adrenergic and Dopaminergic Receptors.” Transl Psychiatry 11(1) (2021): 59. doi: 10.1038/ s41398-020-01171-z.

8. M. van der

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